Abstract: Based on the wind, mean sea level pressure and air temperature data obtained along the Yellow Sea coast from 1973 to 2016, the spatio-temporal mode on the seasonal and interannual variability of mean monthly wind stress, wind speed, pressure and air temperature field in the Yellow Sea were studied with the methods of Rotated Empirical Orthogonal Function (REOF), harmonic analysis and the delay correlation analysis. The results show that the seasonal and interannual variability of wind stress and wind speed field can be basically divided into four spatio-temporal modes. The spatial distribution of wind stress mode is not the same as that of wind speed mode. The seasonal period components of wind stress and wind speed mode are generally unstable. The interannual variation of wind stress and wind speed field mode intensity decreases linearly, which has a significant effect on the seasonal and interannual circulations and the physical and chemical element fields in the Yellow Sea. The seasonal and interannual variability of pressure and air temperature field can be divided into two spatio-temporal modes. The phases of seasonal periodic components of pressure and air temperature mode are all quasi-stable seasonal variability and the amplitudes are unstable in seasonal variability. The interannual variation of pressure mode is in a quasi-equilibrium state. The seasonal and interannual variability of the large-scale atmospheric pressure system is an important influencing factor on the pressure field mode of the Yellow Sea. The interannual variation of air temperature mode shows a trend of significant linear warming. Air-sea and land-air heat exchange effect has a significant influence on the mode of seasonal and interannual variation in air temperature field.